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These PUFAs are different from omega-6 PUFAs like arachidonic acid and play important roles in tumour microenvironment through competitive integration into cell membranes and in enzymatic metabolism through the cyclooxygenase-2 (COX-2) or lipoxygenase pathways
Specifically, NAD stimulates the ATP synthesis in cellular mitochondria
Dhanasekaran, Benjamin K
They can be reactivated following treatment withdrawal, often contributing to tumor relapse [29]
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